ARUMUGAM SURESH,NATRAJAN MUNINATHAN,KUPPUSAMY BASKAR,RENUKA SIDDARAMEGOWDA
DOI: https://doi.org/Monosodium Glutamate (MSG) is a food additive frequently utilised to intensify the flavour of food. It includes the physical reactions linked to the intake or exposure to MSG, such as possible negative effects and interactions with biological systems. The study concentrated on utilising molecular docking methods to examine the interactions and binding strengths between curcumin, a natural compound known for its hepatoprotective properties, and particular target proteins related to liver health. The study examines how curcumin interacts with liver proteins to safeguard the liver by forming strong bonds with Heme Oxygenase-1 (HO-1), Nuclear Factor-Kappa B (NF-κB), Cytochrome P450 2E1 (CYP2E1), Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-γ), and AMP-Activated Protein Kinase (AMPK). Molecular docking studies revealed detailed information about the interactions between curcumin and these proteins. Curcumin shows a high binding affinity with HO-1, suggesting its ability to impact gene expression and improve the liver's ability to resist harmful substances. Curcumin has the ability to efficiently interfere with the NF-κB pathway, demonstrating promising anti-inflammatory properties. Its interaction with CYP2E1 implies involvement in the regulation of drug metabolism that is harmful to the liver. Curcumin's interaction with PPAR-γ suggests its ability to control gene expression related to lipid metabolism, providing therapeutic advantages for metabolic disorders. Curcumin's interaction with AMPK indicates its involvement in controlling cellular energy metabolism. The results highlight curcumin's substantial potential as a versatile treatment for protecting the liver and its intriguing implications for liver-related conditions. Additional experimental validation is necessary before applying these docking results in clinical settings.
