DR. DHARANIDEVI. S,DR.POORANA PRIYA.P,DR.B. SARAVANAKUMAR
DOI: https://doi.org/Alcoholic liver disease [ALD], remains a important universal health presenting presenting a range from steatosis to cirrhosis. Precise evaluation of severity of illness is important for management and prognosis. This plan of this research work is to assess the usefulness of comprehensive haematological parameters coupled with non-invasive prognostic scoring systems, specifically the ABIC score, Maddrey’s Discriminant function(MDF),Glasgow Alcoholic Hepatitis score(GAHS) and AST to Platelet ratio index(APRI) in determining the severity of ALD. Materials and Methods: This cross sectional study was conducted for 50 patients retrospectively in patients who were diagnosed with ALD. Detailed haematological parameters including complete hemogram, LFT and coagulation profiles were analysed. Non-invasive prognostic scores were evaluated for each patient. Correlations between haematological alterations and prognostic scores with clinical outcomes were assessed. Results:Significant hematological alterations were observed in ALD patients including alteration in Hb% levels , WBC , Platelet count and LFT. The ABIC score indicated low survival rates for 26 study cases and intermediate survival for 24 patients. The MDF score associated considerably with PT levels[r=0.936,p<0.001]identifying 26 participant with severe alcoholic hepatitis. The GAHS score demonstrated significant correlations with WBC count [r=0.32,p<0.001].Eleven patients had significant cirrhosis with complications, reflected by APRI score >1.0 with significant p<0.005.Conclusion: The findings in our study demonstrated that such an integrated approach enhances the accuracy of the disease staging, guides clinical decision making and improves patient outcomes in ALD.
