WAFAA ELSAYED ELSAADANY, RAGHAD ABDULAZIZ ALAKKAS, LATIFA SALEH ALRAKAYAN, THIKRA ALI ZAIRI, GHADI ALI SHAMAKHI, JURI ABDULLAH ALGHOFAILI, RAGHAD ABDUH ALQAHTANI, ABDULAZIZ SAAD ALQUHAIBI ,TURKI SAEED ALKAHTANI, FARIS ABDULRAHIM ALOMIR, WAAD ABDULELAH ALDURAYWISH, MOHAMMED ALI SAEED ALZAHRANI, FATIMAH ABDULWAHED ALSHAMMASI
DOI: https://doi.org/Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease often associated with immune dysregulation and skin barrier dysfunction. Recent interest has focused on the role of micronutrients, particularly vitamin D, in influencing disease severity and management.
Objectives: This systematic review aims to evaluate the association between serum vitamin D levels and the severity of AD, and to assess the efficacy of vitamin D supplementation in affected populations.
Methods: Following PRISMA 2020 guidelines, we conducted a structured search across PubMed, Scopus, Web of Science, Embase, and Google Scholar for English-language studies published between 2010 and 2025. Inclusion criteria comprised RCTs, observational studies, and meta-analyses examining serum 25(OH)D levels or vitamin D supplementation in pediatric or adult AD patients. Data extraction and quality assessment were conducted independently by two reviewers.
Results: Seventeen studies met the inclusion criteria. Most reported a significant inverse correlation between serum vitamin D levels and AD severity. Several RCTs demonstrated reductions in SCORAD and EASI scores following vitamin D supplementation, especially in children with baseline deficiency. However, a few studies reported no significant benefit, suggesting variability based on age, gender, and baseline vitamin D status.
Conclusion: Vitamin D deficiency is associated with increased AD severity, and supplementation appears beneficial in selected populations. Routine vitamin D screening and targeted supplementation may represent valuable adjunct strategies in AD management, pending further standardized research.
