DR HAFIZA SANA IMTIAZ , DR SARWAT NAZIR , SEHAR IMTIAZ
DOI: https://doi.org/10.5281/zenodo.19591532Background: Pree clamps is a pregnancy hypertensive disease that is a leading cause of maternal and neonatal morbidity and mortality in the world. The early detection of women at risk is a key clinical challenge. A possible predictor is Mean Platelet Volume (MPV), which is an indicator of platelet activation, whose evidence is still inconclusive.
Objective: the aim of the study is to establish the diagnostic value of Mean Platelet Volume to assess pre-eclampsia.
Methodology: This was a prospective cohort study which was carried out in the Department of Obstetrics and Gynecology, Sir Ganga Ram Hospital, Lahore, during September 2025 and December 2025. The total number of pregnant women (20-40 gestation) who were enrolled via consecutive sampling met the inclusion criteria was 200. The hematology analyzer was an automated hematology analyzer that was used to measure baseline MPV. Those who conceived were tracked to delivery to develop preeclampsia which was the presence of blood pressure of 140/90 mmHg with a positive protein level of 1 or greater on a dipstick at 20 weeks of gestational age. Parameters of diagnostic accuracy such as sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were determined.
Results: High MPV (>10.95 fL) had moderate sensitivity and specificity of about 78-82 and 70-76 respectively in the prediction of preeclampsia. It was also found that PPV and NPV were clinically acceptable. The mean values of MPV were much higher in women who developed preeclampsia than in normotensive controls (p<0.05).
Conclusion: MPV is a cheap, easy to use and hematological parameter that depicts medium accuracy in the prediction of preeclampsia. It can be used as a beneficial additional tool to stratify risks in limited resources at the early stage. More extensive studies in the future are suggested to confirm this.
