DR. DHARANIDEVI.S,DR. SONTISULOCHANA
DOI: https://doi.org/Background: Psoriasis is a prevalent inflammatory skin condition described by diverse histomorphological features affecting both the epidermis and dermis .Using histological criteria to identify psoriasis is essential for directing therapy regimens.. Additionally, there exist psoriasiform lesions that mimic psoriasis, necessitating accurate differentiation.
Methods: We conducted an analysis of sixty cases diagnosed with psoriasis vulgaris and pustular psoriasis, confirmed histopathologically and exclusive of psoriasiform dermatitis, over a six-year period in the Department of Pathology. Hematoxylin and eosin stains were used on tissue sections, which were then assessed for various morphological characteristics.
Findings: Of the cases examined, 88.33% of patients had psoriasis vulgaris and 11.67% as pustular psoriasis. The condition exhibited a greater occurrence among people in their twenties and forties, with a predominance of males. Frequently impacted areas involved the upper and lower limbs. Important histopathological observations consisted of hyperkeratosis (100%), parakeratosis (100%), spongiosis (91.67%), papillomatosis (73.33%), alongside hypogranulosis (55%) or agranulocytosis (45%). Furthermore, widened and convoluted vessels were noted in 88.33% and 43.33% of instances.
Conclusions: Histopathological evaluation continues to be the foundation for identifying psoriasis. In instances where distinct Munro microabscesses and Kogoj's pustules are absent, additional epidermal characteristics like hyperkeratosis , parakeratosis, spongiosis, papillomatosis along with engorged and twisted dermal capillaries, offer substantial supporting proof of psoriasis. The decrease or lack of the granular layer is especially distinctive and indicates the underlying impaired keratinocyte proliferation in psoriasis.
