UMA MAHESWARI,VALLALKANI ,SULOCHANA SONTI,DR. AMUDHA. D
DOI: https://doi.org/Background
Chronic Kidney Disease (CKD) is an intriguing phenomenon that impacts hematological indices, boxes the various organ systems in the body and also affects the functional wellbeing of an individual affected by it. Since, there are multiple causative factors of CKD it’s imperative to understand the effects as well as the damage it causes in the body.Hemodialysis, has been shown to have a positive benefit in terms of improving the hematological investigations.This study aims to offer foresight into the role of hemodialysis in mitigating hematological abnormalities in CKD patients, ultimately aiming towards enhancement of clinical management strategies.
Objective
To examine the correlation between chronic kidney disease and hematological measures, and to study the repercussions of hemodialysis on these variables.
Subjects and Methods
This observational study was conducted at a tertiary care hospital between September 2024 and March 2025, involving 60 subjects divided into two groups, each comprising 30 participants.. Group I included patients with chronic kidney disease (CKD) not undergoing hemodialysis (NDD-CKD), while Group II comprised patients with CKD on hemodialysis (DD-CKD).
Detailed medical histories were collected for all participants and appropriate investigations performed on both the groups and data represented and analyzed for correlation.
Results:Dialysis-dependent CKD patients (Group II) tend to be older, predominantly male, and have a higher prevalence of diabetes mellitus and anemia compared to non-dialysis CKD patients (Group I). Group II demonstrates significantly improved hematological indices, including higher hemoglobin, hematocrit, RBC count, and erythrocyte parameters, while exhibiting lower platelet count but increased MPV and WBC indices. Biochemical markers indicate enhanced waste elimination, calcium-phosphate balance, and nutritional status, with lower urea, creatinine, phosphorus, and parathyroid hormone levels. Extended dialysis further improves hematological parameters, reducing RDW and boosting erythrocyte quality, while biochemical indicators continue to stabilize. These findings emphasize the crucial role of prolonged dialysis in optimizing hematological and biochemical health in CKD patients.
Conclusion: CKD serves as an influential factor on all hematological parameters and hemodialysis further modulates the effect.
