DR DIVYA VASIREDDY,DR PRASNA S,DR S.S DIVYA PRIYA,DR. MADHUMITHA M
DOI: https://doi.org/Introduction
Our study aims to formulate and evaluate the efficacy of a novel topical cream incorporating Aloe vera extract, Silver nitrate, Coconut oil, Olive oil, Tea tree oil, and Guar gum for the treatment of first-degree burns, with the goal of enhancing wound healing and minimizing scar formation-animal model.
Material and Methods
In this study, twelve female Wistar rats (8–12 weeks old, 120–180 g) were quarantined for seven days under controlled environmental conditions before undergoing a 12‑hour fast. Each animal was then anesthetized with intramuscular ketamine (50 mg/kg) and xylazine (10 mg/kg), and a standardized 1 cm chemical burn was inflicted on the dorsum. The rats were randomized into four groups of three: Group 1 remained uninjured as healthy controls; Group 2 received the burn injury with no subsequent treatment; Group 3 received daily topical applications of a standard silver‑based dressing (Silverex); and Group 4 received daily applications of the investigational cream. Treatments were administered once daily for 14 days, during which animals were monitored twice daily for general health, wound appearance, and body‑weight changes.
Results
The investigational cream markedly accelerated healing compared to both untreated and silver‑treated wounds. By Day 14, wounds in the novel‑cream group (Group 4) exhibited 95 ± 1 % area reduction versus 87 ± 3 % with Silverex (Group 3) and 68 ± 6 % in untreated controls (Group 2), while healthy controls (Group 1) of course showed no wound. Complete epithelialization occurred fastest in Group 4 (8.7 ± 0.7 days), followed by Group 3 (10.8 ± 0.9 days) and Group 2 (14.2 ± 1.1 days).
Conclusion
Our data demonstrate that the novel topical cream significantly accelerates superficial wound closure, enhances re‑epithelialization, and promotes organized collagen deposition more effectively than both untreated controls and a standard silver‑based dressing.
