DR. KAVITHA S,DR. KARTHIKA,DR. ANUSUYA DR. ANUSUYA
DOI: https://doi.org/Introduction: Pancytopenia is an everyday finding in clinical practice, often associated with many critical illnesses. Suspicion arises when a patient presents with a triad of symptoms due to anemia, leukopenia, and thrombocytopenia. Primary causal condition coupled with the severity influences prognosis and treatment course. We aimed to analyze the clinical features in pancytopenic patients; and further to evaluate hematological distribution, inclusive of bone marrow aspiration. Methodology: Prospective cross-sectional study design was exercised in a 6 month span, from July to December 2023 at the Department of Hematology. In total, 106 patients with pancytopenia aged 15 to 65 years, were reviewed to scrutinize their demographic and clinical details with focus on their peripheral picture study and bone marrow analysis. Results: Of the 106 cases investigated, a hefty number were in the 15-25 years age group (40.57%), with a male predominance (57.55%). Most common symptoms were generalized weakness (87.74%) and fever (59.43%). Physical findings included pallor (83.02%), hepatomegaly (24.53%), and splenomegaly (16.98%). Dimorphic anemia (24.53%) was the predominant blood picture, followed by normocytic normochromic picture (12.26%) and normocytic hypochromic picture (5.66%). Megaloblastic erythropoiesis (72.64%) was the commonest bone marrow finding, seconded by iron deficiency anemia (12.26%). Conclusion: Comprehensive workup, consisting of clinical findings, hematological scrutiny, and bone marrow exploration, is imperative for dictating the cause in pancytopenic patients. These findings also help in further evaluation.
